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Inhibitors?ScreeningLibraries?Proteins

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CHS-828(Standard)

Cat.No.:HY-10079R

CASNo.:200484-11-3

Synonyms:GMX1778(Standard)

分?式:C??H??ClN?O

分?量:371.86

作?靶点:NAMPT;Apoptosis

作?通路:MetabolicEnzyme/Protease;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性CHS-828(Standard)是CHS-828的分析标准品。本产品?于研究及分析应?。CHS-828(GMX1778)是?种竞

争性的烟酰胺磷酸化转移酶抑制剂(NAMPT)，IC50值+?平发挥细胞毒性作?，具有较强的抗癌活性[1]。

IC50TargetIC50:25nM(NAMPT)[1].

REFERENCES

[1].WatsonM,etal.ThesmallmoleculeGMX1778isapotentinhibitorofNAD+biosynthesis:strategyforenhancedtherapyinnicotinicacid

phosphoribosyltransferase1-deficienttumors.MolCellBiol.2009Nov;29(21):5872-88.

[2].CernaD,etal.Inhibitionofnicotinamidephosphoribosyltransferase(NAMPT)activitybysmallmoleculeGMX1778regulatesreactive

oxygenspecies(ROS)-mediatedcytotoxicityinap53-andnicotinicacidphosphoribosyltransferase1(NAPRT1)-dependentmanner.JBiol

Chem.2012Jun22;287(26):22408-17.

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