Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
CDK2/PIM1-IN-1
Cat.No.:HY-173224
分?式:C??H??N?O?
分?量:421.49
作?靶点:CDK;Pim
作?通路:CellCycle/DNADamage;JAK/STATSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性CDK2/PIM1-IN-1是CDK2(IC50:0.27μM)和PIM1(IC50:0.67μM)激酶的抑制剂。CDK2/PIM1-IN-1可诱导
细胞凋亡(apoptosis)，并降低促进肿瘤的TNF-α表达。CDK2/PIM1-IN-1具有抗肿瘤活性。
IC50TargetCDK2PIM1
0.27μM(IC50)0.67μM(IC50)
体外研究CDK2/PIM1-IN-1(Compound6b)(24h)showsantiproliferativeeffectsonMCF7cells(IC50:5.54μM),HCT-
116cells(IC50:2.62μM),HepG2cells(IC50:3.99μM)andHeLacelllines(IC50:8.31μM),withmoderate
safetyinthenormalbreastcelllineMCF-10A(IC50:39.44μM)[1].
CDK2/PIM1-IN-1(24h)inhibitsHCT116celllineattheG0-G1phase(%G0-G1:83.43%)andinduced
significantearly(8.28%)andlate(20.09%)cellapoptosis[1].
CDK2/PIM1-IN-1(24h)showsinhibitoryeffectsonbothCDK(IC50:0.27μM)andPIM1(IC50:0.67μM)in
HCT116celllines[1].
CellViabilityAss