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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

BIIB021(Standard)

Cat.No.:HY-10212R

CASNo.:848695-25-0

Synonyms:CNF2024(Standard)

分?式:C??H??ClN?O

分?量:318.76

作?靶点:HSP;Autophagy

作?通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;

Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性BIIB021(Standard)是BIIB021的分析标准品。本产品?于研究及分析应?。BIIB021(CNF2024)是?种合成的

具有?服活性的HSP90抑制剂，Ki值和EC50值分别为1.7nM和38nM。

IC50TargetKi:1.7nM(HSP90)[1]

REFERENCES

[1].Lundgren,Karen.,etal.BIIB021,anorallyavailable,fullysyntheticsmall-moleculeinhibitoroftheheatshockproteinHsp90.Molecular

CancerTherapeutics(2009),8(4),921-929.

[2].B?llB,etal.Heatshockprotein90inhibitorBIIB021(CNF2024)depletesNF-kappaBandsensitizesHodgkinslymphomacellsfor

naturalkillercell-mediatedcytotoxicity.ClinCancerRes.2009Aug15;15(16):5108-16.

[3].YinX,etal.BIIB021,anovelHsp90inhibitor,sensitizesheadandnecksquamouscellcarcinomatoradiotherapy.Int