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Inhibitors?ScreeningLibraries?Proteins

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Betrixaban(Standard)

Cat.No.:HY-10268R

CASNo.:330942-05-7

Synonyms:PRT054021(Standard)

分?式:C??H??ClN?O?

分?量:451.91

作?靶点:FactorXa

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Betrixaban(Standard)是Betrixaban的分析标准品。本产品?于研究及分析应?。Betrixaban(PRT054021)

是?种有效的，具有?服活性的选择性factorXa(fXa)抑制剂，IC50为1.5nM。Betrixaban具有抗?栓形成

效果。

IC50TargetIC50:1.5nM(fXa)[1]

Ki:0.117nM(fXa),1.8μM(hERG)[1]

REFERENCES

[1].ZhangP,etal.DiscoveryofBetrixaban(PRT054021),N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-

methoxybenzamide,ahighlypotent,selective,andorallyefficaciousfactorXainhibitor.BioorgMedChemLett.2009Apr15;19(8):21

[2].LuG,etal.AspecificantidoteforreversalofanticoagulationbydirectandindirectinhibitorsofcoagulationfactorXa.NatMed.2013

Apr;19(4):446-51.

[3].ChanNC,etal.Profileofbetrixabananditsp