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Fezagepras(Standard)

Cat.No.:HY-100775AR

CASNo.:1002101-19-0

Synonyms:Setogepram(Standard);PBI-4050(Standard)

分?式:C??H??O?

分?量:206.28

作?靶点:FreeFattyAcidReceptor;GPR84

作?通路:GPCR/GProtein

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Fezagepras(Standard)是Fezagepras的分析标准品。本产品?于研究及分析应?。Fezagepras

(Setogepram)是?种具有?服活性的GPR40激动剂和GPR84拮抗剂或反向激动剂[1]。Fezagepras减轻肾

，肝和胰腺纤维化[1][2]。Fezagepras具有抗纤维化，抗炎和抗增殖作?[2]。

IC50TargetGPR40,GPR84[1]

REFERENCES

[1].LiY,etal.FattyacidreceptormodulatorPBI-4050inhibitskidneyfibrosisandimprovesglycemiccontrol.JCIInsight.2018May

17;3(10).pii:120365.

[2].GrouixB,etal.PBI-4050ReducesStellateCellActivationandLiverFibrosisthroughModulationofIntracellularATPLevelsandthe

LiverKinaseB1/AMP-ActivatedProteinKinase/MammalianTargetofRapamycinPathway.JPharmacolExpTher.2018Oct;367(1):71-81.

McePdfHeight

Caution:Producthasnotbeenfullyvalidate