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Inhibitors?ScreeningLibraries?Proteins

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Vericiguat-d6

Cat.No.:HY-16774S2

Synonyms:BAY1021189-d6

分?式:C??H??D?F?N?O?

分?量:432.42

作?靶点:Isotope-LabeledCompounds;GuanylateCyclase

作?通路:Others;GPCR/GProtein

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Vericiguat-d6(BAY1021189-d6)是氘代标记的Vericiguat.Vericiguat(BAY1021189)是有效的，有?服活性

的，可溶的鸟苷酸环化酶(guanylatecyclase)刺激物。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].FollmannM,etal.DiscoveryoftheSolubleGuanylateCyclaseStimulatorVericiguat(BAY1021189)fortheTreatmentofChronicHeart

Failure.JMed