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Leflunomide-13C6

Cat.No.:HY-B0083S1

Synonyms:HWA486-13C;RS-34821-13C;SU101-13C

666

分?式:C???C?H?F?N?O?

分?量:272.13

作?靶点:Isotope-LabeledCompounds;DihydroorotateDehydrogenase;

Bacterial;EndogenousMetabolite

作?通路:Others;MetabolicEnzyme/Protease;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Leflunomide-13C6(HWA486-13C6)是13C标记的Leflunomide.Leflunomide是?种嘧啶合成抑制剂，通过

抑制?氢乳清酸脱氢酶(DHODH)起作?，具有抗风湿的作?。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmac