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Ivosidenib-d5

Cat.No.:HY-18767S3

CASNo.:2329582-02-5

Synonyms:AG-120-d5

分?式:C??H??D?ClF?N?O?

分?量:587.99

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ivosidenib-d5(AG-120-d5)是氘代标记的Ivosidenib.Ivosidenib(AG-120)是异柠檬酸脱氢酶1的突变体酶(

mIDH1enzyme)的?服活性抑制剂，它使d-2-hydroxyglutatrate(2-HG)在体内降低。Ivosidenib具有良好

的的安全性和临床活性，具有AML研究的潜?。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalid