基本信息

---

下载

文档摘要

---

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

D-G23

Cat.No.:HY-122583

CASNo.:1225141-73-0

分?式:C??H??N?O?

分?量:354.4

作?靶点:RAD51

作?通路:CellCycle/DNADamage

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性D-G23是?种选择性RAD52抑制剂。D-G23破坏RAD52介导的DNA修复途径，抑制BRCA1-和BRCA2缺陷

癌细胞的?长。D-G23有望?于BRCA1/2突变引起的同源重组相关癌症的研究，如遗传性乳腺癌和卵巢癌

[1]。

REFERENCES

[1].HuangF,etal.TargetingBRCA1-andBRCA2-deficientcellswithRAD52smallmoleculeinhibitors.NucleicAcidsRes.2016May

19;44(9):4189-99.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您?边的抑制剂?师