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Inhibitors?ScreeningLibraries?Proteins

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Biotin-13C5

Cat.No.:HY-B0511S3

Synonyms:VitaminB7-13C;VitaminH-13C;D-Biotin-13C

555

分?式:C???C?H?N?O?S

分?量:241.21

作?靶点:Isotope-LabeledCompounds;EndogenousMetabolite

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Biotin-13C5(VitaminB7-13C5)是13C标记的Biotin.Biotin，即维?素B7，是?体五种羧化酶的辅酶，参与

脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异?。Biotin是细胞?长、脂肪酸产?以及脂肪和氨基酸代谢的

必需物质。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Zempleni,etal.Biotinbiochemistryandhumanrequirements.JNutrBiochem,1999.10(3):p.128-38.

[3].Mock,D.M..Biotinstatus:whicharevalidindicatorsandhowdoweknow?JNutr,1999.129