Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
AG1295(Standard)
Cat.No.:HY-101957R
CASNo.:71897-07-9
分?式:C??H??N?
分?量:234.3
作?靶点:PDGFR
作?通路:ProteinTyrosineKinase/RTK
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性AG1295(Standard)是AG1295的分析标准品。本产品?于研究及分析应?。AG1295是?种选择性??板衍
??长因?受体(PDGFR)酪氨酸激酶抑制剂。AG1295能抑制PDGFR的?磷酸化，对EGF受体的?磷酸化?
效[1][2][3][4]。
IC50TargetPDGFR[1]
REFERENCES
[1].ZhengY,etal.Platelet-derivedgrowthfactorreceptorkinaseinhibitorAG1295andinhibitionofexperimentalproliferative
vitreoretinopathy.JpnJOphthalmol.2003Mar-Apr;47(2):158-65.
[2].Inhibitionofaorticallograftvasculopathybylocaldeliveryofplatelet-derivedgrowthfactorreceptortyrosine-kinaseblockerAG-1295.
Transplantation.2002Nov15;74(9):1335-41.
[3].KovalenkoM,etal.Selectiveplatelet-derivedgrowthfactorreceptorkinaseblockersreversesis-transformation.CancerRes.1994Dec
1;54(23):6106-14.
[4].LudewigD,etal.PDGFreceptorkinaseblockerAG1295