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Inhibitors?ScreeningLibraries?Proteins
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5A2-SC8TFA
Cat.No.:HY-145799A
分?式:C??H???N?O??S?.xC?HF?O?
作?靶点:Liposome
作?通路:MetabolicEnzyme/Protease
储存?式:-20°C,sealedstorage,awayfrommoistureandlight
*Insolvent:-80°C,6months;-20°C,1month(sealed
storage,awayfrommoistureandlight)
BIOLOGICALACTIVITY
?物活性5A2-SC8TFA是?种脂质纳?粒?(LNPs)中的可电离氨基脂质，显?出?效的递送潜?和较低的体内毒性
，能够将?RNA(如siRNA和miRNA)有效地递送到肿瘤细胞中。5A2-SC8TFALNPs可以赋予RNA在肝脏内
独特的递送命运，从?改变癌症模型的治疗结果[1][2][3]。
体外研究TheApoEproteincoronaadsorbsonthesurfaceof5A2-SC8LNPsbindstoLDL-Ronthesurfaceof
hepatocytesandundergoesreceptor-mediatedendocytosis,andistakenupbyhepatocytes[2].
体内研究5A2-SC8(75mg/kg;i.v.;single-dose)iswelltoleratedanddoesnotaffectsurvivalinmicewithchronic
aggressivehepatocellularcarcinoma[1].5A2-SC8(0.5mg/kg;i.v.;single-dose)canpassthefirstbarrierof
KupffercellsintheliverandbeinternalizedintohepatocytesinthepresenceofsiFVIIlabeledwithCy5.5dye
[2].
客户使?本产品发表的科研?献
?Pharmaceutics.2022,14(10),2129.
Seemorecustomervalidationsonwww.MedChemE
REFERENCES
[1].ZhouK,NguyenLH,MillerJB,etal.Modulardegradabledendrimersenablesmall