基本信息
文件名称：Phenytoin-d5-5-5-Diphenylhydantoin-d-sub-5-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-24
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Phenytoin-d5

Cat.No.:HY-B0448S2

Synonyms:5,5-Diphenylhydantoin-d5

分?式:C??H?D?N?O?

分?量:257.3

作?靶点:Isotope-LabeledCompounds;VirusProtease;Sodium

Channel

作?通路:Others;Anti-infection;MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Phenytoin-d5(5,5-Diphenylhydantoin-d5)是氘代标记的Phenytoin.Phenytoin(5,5-Diphenylhydantoin)是

?种有效的电压门控Na+通道(VGSCs)阻滞剂。Phenytoin具有抗癫痫活性，也可减少??乳腺肿瘤的?长和

转移。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.