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Inhibitors?ScreeningLibraries?Proteins
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Galectin-3-IN-6
Cat.No.:HY-173235
CASNo.:2604662-64-6
分?式:C??H??Cl?F?N?O?
分?量:645.45
作?靶点:Galectin
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Galectin-3-IN-6(Compound12)是?种具有?服活性的半乳糖凝集素-3(Gal-3)抑制剂，对Gal-3的IC50值为
12nM，Kd值为13nM。在CCl4诱导的??急性肝损伤和纤维化模型中，Galectin-3-IN-6可使纤维化标志物
胶原蛋?-1和α-平滑肌肌动蛋?(αSMA)?平分别显著降低64%和71%，具有显著的抗纤维化活性。
Galectin-3-IN-6可?于纤维化疾病、癌症和??管疾病的研究[1]。
REFERENCES
[1].ZumbrunnC,etal.DiscoveryofGalactopyranose-1-carboxamidesasaNewClassofSmall,Novel,Potent,Selective,andOrallyActive
Galectin-3Inhibitors.ChemMedChem.2025Mar12:e202401012.
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