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Inhibitors?ScreeningLibraries?Proteins

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Curcumin-d3

Cat.No.:HY-N0005S1

Synonyms:Diferuloylmethane-d;NaturalYellow3-d;Turmericyellow-d

333

分?式:C??H??D?O?

分?量:371.4

作?靶点:Isotope-LabeledCompounds;Ferroptosis;EpigeneticReader

Domain;Mitophagy;InfluenzaVirus;Keap1-Nrf2;Histone

Acetyltransferase;Autophagy

作?通路:Others;Apoptosis;Epigenetics;Autophagy;Anti-infection;NF-

κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Curcumin-d3(Diferuloylmethane-d3)是氘代标记的Curcumin.Curcumin(Diferuloylmethane)，是?种天然

酚类化合物，是?酰转移酶p300/CREB结合蛋?特异性抑制剂，抑制组蛋?/?组蛋?的?酰化和组蛋??酰

转移酶依赖的染?质转录。Curcumin对NF-κb和MAPKs有抑制作?，并具有抗炎、抗氧化、抗增殖和抗?

管?成等多种药理作?。Curcumin通过Keap1半胱氨酸修饰诱导Nrf2蛋?的稳定。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs