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Inhibitors?ScreeningLibraries?Proteins
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GSK-3β/CK-1δ-IN-1
Cat.No.:HY-173494
分?式:C??H??F?N?O
分?量:410.39
作?靶点:GSK-3;CaseinKinase
作?通路:PI3K/Akt/mTOR;StemCell/Wnt;CellCycle/DNADamage
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性GSK-3β/CK-1δ-IN-1(8d)是?种能够透过?脑屏障的GSK-3β/CK-1δ双重抑制剂，对GSK-3β和CK-1δ
的IC50值分别为0.77μM和0.57μM。GSK-3β/CK-1δ-IN-1(8d)可?于神经母细胞瘤的研究。
IC50TargetGSK-3βCK-1δ
0.77μM(IC50)0.57μM(IC50)
REFERENCES
[1].VinitaSharma,etal.Discoveryof6-aminopyridineclubbedheterocyclesaspotentdualGSK-3β/CK-1δinhibitorsforthetreatmentof
Alzheimersdisease.BioorgChem.2025Jun1:159:108409.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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