Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

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Ferroptosisinducer-7

Cat.No.:HY-172803

CASNo.:2723569-00-2

分?式:C??H??NO?

分?量:489.56

作?靶点:Ferroptosis;ERK;MEK;p38MAPK

作?通路:Apoptosis;MAPK/ERKPathway;StemCell/Wnt

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ferroptosisinducer-7是?种?服有效的选择性铁死亡诱导剂，通过作?于肌醇1,4,5-三磷酸受体(IP3R)/钙释

放激活钙通道蛋?(ORAI)实现。Ferroptosisinducer-7在免疫介导的?髓衰竭中能缓解贫?症状、抑制?髓

CTL激活以及改善免疫介导的?髓衰竭造?功能??表现出显著作?。Ferroptosisinducer-7可?于再?障碍

性贫?的研究[1]。

体外研究Ferroptosisinducer-7(Compound3a-M1)(1-10μM,72h)significantlyinhibitstheproliferationofCD8+T

cells,aswellasthereleaseofIFN-γandTNF-αinlymphnodesofBALB/cmice[1].

Ferroptosisinducer-7(7.5-480μM,72h)selectivelyinhibitstheproliferationofcytotoxiclymphocyteline-2

(CTLL-2)comparedtootherimmunecelllines[1].

Ferroptosisinducer-7(7.5-30μM,16h)suggeststheinhibitionofCTLfunctionisduetotheactivationof

FerroptosisinCTLL-2treatedwithIL-2[1].

Ferroptosisinducer-7(10μM,45min)increasestheextracellularCa2+influxomCTLs,whichistriggeredby