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VU0469650hydrochloride

Cat.No.:HY-W714513

分?式:C??H??ClN?O

分?量:400.94

作?靶点:mGluR

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性VU0469650hydrochloride是?种脑渗透性的代谢性?氨酸受体1(mGluR1)负变构调节剂。VU0469650

hydrochloride在表达?mGluR1(IC50=99nM)的细胞中抑制?氨酸诱导的钙通量。VU0469650

hydrochloride有望?于焦虑、成瘾、癫痫等中枢神经系统疾病的研究。

IC50TargetmGluR1

REFERENCES

[1].LovellKM,etal.N-Acyl-N-arylpiperazinesasnegativeallostericmodulatorsofmGlu1:identificationofVU0469650,apotentand

selectivetoolcompoundwithCNSexposureinrats.BioorgMedChemLett.2013Jul1;23(13):3713-8.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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