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Inhibitors?ScreeningLibraries?Proteins

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Plateletaggregation-IN-3

Cat.No.:HY-176060

CASNo.:1029802-21-8

分?式:C??H??ClN?

分?量:251.76

作?靶点:HistamineReceptor;AdrenergicReceptor;5-HTReceptor

作?通路:GPCR/GProtein;Immunology/Inflammation;Neuronal

Signaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Plateletaggregation-IN-3(Compound5)是H2histaminereceptors、α2(A,C)--肾上腺素能受体(α2-AR)和

5-HT2(B,C)serotoninreceptors的配体。Plateletaggregation-IN-3可以抑制ADP和胶原诱导的??板聚集

，也可以调节肿瘤细胞诱导的??板聚集(TCIPA)。Plateletaggregation-IN-3有望?于??管疾病抗??板治

疗及预防癌症相关?栓形成和肿瘤转移的研究。

IC50TargetH2Receptorα2-adrenergicreceptorHistamineReceptor

REFERENCES

[1].HanteNK,etal.Effectofmono-guanidine-likederivativesonplateletaggregationandtumourcellinducedplateletaggregation.RSC

MedChem.2025Jan31;16(4):1695-1704.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.