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5-O-DMT-N2-Ibu-2-OMe-G

Cat.No.:HY-W460666

CASNo.:251647-50-4

分?式:C??H??N?O?

分?量:713.78

作?靶点:DrugIntermediate

作?通路:Others

储存?式:4°C,storedundernitrogen

*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)

BIOLOGICALACTIVITY

?物活性5-O-DMT-N2-Ibu-2-OMe-G是?种?于合成反义寡核苷酸的关键中间体。5-O-DMT-N2-Ibu-2-OMe-G参与

构建具有特定序列的反义寡核苷酸，这些反义寡核苷酸能够与靶向mRNA互补结合。5-O-DMT-N2-Ibu-2-

OMe-G阻断mRNA的翻译过程，从?抑制特定蛋?质的表达，发挥调控基因表达的作?。5-O-DMT-N2-Ibu-

2-OMe-G有望?于遗传性疾病和肿瘤的研究[1]。

REFERENCES

[1].TajSA,etal.Processdevelopmentforthesynthesisof5-O-(4,4-dimethoxytrityl)-N2-isobutyryl-2-O-(2-methoxyethyl)-guanosine--a

potentialprecursorforthesecondgenerationantisenseoligonucleotides:animprovedprocessforthepreparationof2-O-alkyl-2,6-

diaminopurineriboside.NucleosidesNucleotidesNucleicAcids.2003May-Aug;22(5-8):1327-30.

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