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Inhibitors?ScreeningLibraries?Proteins
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TRPA1-IN-4
Cat.No.:HY-172898
分?式:C??H??F?N?O?S
分?量:497.46
作?靶点:TRPChannel
作?通路:MembraneTransporter/IonChannel;NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性TRPA1-IN-4(12)是TRPA1的抑制剂，其IC50值为45nM。TRPA1-IN-4(12)可?于疼痛研究。
体内研究TRPA1-IN-4(12,C57BL/6Jmice,50nmoL/10μL,i.pl.(intraplantar))showsstrongnanomolaractivityand
reducespaininmousemodelsusingAITCandFormalin[1].
REFERENCES
[1].ValentinaAlbanese,etal.Identificationofisoxazole-basedTRPA1inhibitorswithanalgesiceffectsinvivo.EurJMedChem.2025May
9:294:117732.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE
1/1MasterofBioactiveMolecules—您?边的抑制剂?师