Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
Trolox(GMP)
Cat.No.:HY-101445G
CASNo.:53188-07-1
分?式:C??H??O?
分?量:250.29
作?靶点:ReactiveOxygenSpecies;Ferroptosis;Apoptosis
作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κ
B;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Trolox(GMP)是GMP级别的Trolox(HY-101445)。GMP级别的?分?可?做细胞疗法中的辅助试剂。Trolox
是?种维?素E的类似物，具有强?的抗氧化作?。Trolox还是?种强?的膜损伤抑制剂。
体外研究Trolox(GMP)hasshowntoprotectmammaliancellsfromoxidativedamage.Trolox(GMP)iseffectivein
preventingmyocytenecrosisincellculturestudiesandinacaninemodeloftwohoursofleftanterior
descendingcoronaryartery(LAD)occlusionfollowedbyfourhoursofreperfusion[1].
Trolox(GMP)couldpreventoxidativestress-inducedapoptosisinthymocytes.Pre-orpost-treatmentofcells
withTrolox(GMP)reducedH2O2-inducedDNAfragmentationtocontrollevelsandbelow.[2].
Trolox(GMP)isahydrophilicanalogofalpha-tocopherolandreportedtoscavengeperoxylradicalsbetter
thanvitaminEinsodiumdodecylsulfatemicellesandinliposomes.Trolox(GMP)prolongs