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Inhibitors?ScreeningLibraries?Proteins
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RSK-IN-2
Cat.No.:HY-173406
CASNo.:3011713-80-4
分?式:C??H??ClN?O?
分?量:512
作?靶点:RibosomalS6Kinase(RSK);Apoptosis
作?通路:MAPK/ERKPathway;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性RSK-IN-2(Compound3e)是RSK的抑制剂，其IC50分别为37.89nM(RSK2)、30.78nM(RSK1)、20.51nM
(RSK3)和91.28nM(RSK4)。RSK-IN-2抑制肿瘤细胞增殖，诱导细胞凋亡(Apoptosis)，并导致细胞周期停滞于
G2/M期。
IC50TargetRSK1RSK2RSK3RSK4
30.78nM(IC50)37.89nM(IC50)20.51nM(IC50)91.28nM(IC50)
REFERENCES
[1].HanC,etal.Discoveryof2,4-dianilinopyrimidinederivativesasnovelp90ribosomalS6proteinkinase(RSK)inhibitors.EurJMed
Chem.2025Jul5;291:117590.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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