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Inhibitors?ScreeningLibraries?Proteins
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PPARagonist6
Cat.No.:HY-172792
分?式:C??H??NO?
分?量:421.57
作?靶点:PPAR
作?通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;Vitamin
DRelated/NuclearReceptor
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性PPARagonist6(compound5a)是PPAR的激动剂，对PPARα，PPARβ/δ和PPARγ的EC50值分别为3.6
μM，2.6μM。PPARagonist6抑制L929细胞中TNFα依赖性NF-κB驱动的报告基因的反式激活[1]。
REFERENCES
[1].CarlosVillarroel-Vicente,etal.Developmentof2-and3-prenylatedquinolinesandtetrahydroquinolineswithPPARactivity:Fromhitto
leadandanovelpan-PPARagonistasapotentialcandidateformetabolicsyndrome.BioorgChem.2025Jun15:160:108450.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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