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Inhibitors?ScreeningLibraries?Proteins

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Naftopidil-d7

Cat.No.:HY-B0391S2

Synonyms:KT-611-d;BM-15275-d

77

分?式:C??H??D?N?O?

分?量:399.53

作?靶点:Isotope-LabeledCompounds;AdrenergicReceptor

作?通路:Others;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Naftopidil-d7(KT-611-d7)是氘代标记的Naftopidil.Naftopidil(KT-611)是?种选择性的alpha1-肾上腺素受

体(α1-adrenoceptor)拮抗剂，对克隆的?类α1a、α1b和α1d亚型肾上腺素受体的亲和?Ki值分别为

3.7nM、20nM、1.2nM，具有抗增殖作?。Naftopidil可?于前列腺增?的研究[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharma