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Inhibitors?ScreeningLibraries?Proteins
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KVA-D-88
Cat.No.:HY-139178
CASNo.:2410550-31-9
分?式:C??H??Cl?F?N?O
分?量:382.19
作?靶点:Phosphodiesterase(PDE)
作?通路:MetabolicEnzyme/Protease
储存?式:Powder-20°C3years
Insolvent-80°C6months
-20°C1month
BIOLOGICALACTIVITY
?物活性KVA-D-88是?种能够透过?脑屏障的PDE4抑制剂，对PDE4B和PDE4D的IC50值分别为140和880nM。
KVA-D-88具有抑制可卡因诱导的?运动活性和敏化作?。KVA-D-88通过选择性抑制PDE4B，减少cAMP降
解，从?调节神经适应性反应。KVA-D-88可?于可卡因成瘾的研究[1]。
IC50TargetPDE4BPDE4D
140nM(IC50)880nM(IC50)
REFERENCES
[1].BurkovetskayaME,etal.KVA-D-88,aNovelPreferablePhosphodiesterase4BInhibitor,DecreasesCocaine-MediatedReward
PropertiesinVivo.ACSChemNeurosci.2020Aug5;11(15):2231-2242.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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