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Inhibitors?ScreeningLibraries?Proteins
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HDAC11-IN-3
Cat.No.:HY-173444
CASNo.:2989934-63-4
分?式:C??H??F?N?O?
分?量:344.29
作?靶点:HDAC;TransferrinReceptor;Apoptosis;Ferroptosis
作?通路:CellCycle/DNADamage;Epigenetics;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性HDAC11-IN-3(CompoundA9)是?种选择性HDAC11抑制剂(IC50:4.1nM)。HDAC11-IN-3对U937和OCI-
AML2急性髓系??病(AML)细胞系具有抑制作?(IC50:10μM)。HDAC11-IN-3具有显著的抗AML活性，能
诱导细胞凋亡(apoptosis)、周期阻滞和分化。HDAC11-IN-3上调了铁转运蛋?转铁蛋?(TF)和转铁蛋?受体(
TFRC)，并激活了p62-Keap1-Nrf2-HMOX1通路，共同导致细胞内铁?平升?，诱导AML细胞铁死亡(
ferroptosis)。HDAC11-IN-3可单独或联合Cytarabine(HY-13605)?于AML研究[1]。
IC50TargetHDAC11
4.1nM(IC50)
REFERENCES
[1].YangM,etal.HDAC11InhibitionasaPotentialTherapeuticStrategyforAML:TargetIdentification,LeadDiscovery,AntitumorPotency,
andMechanismInvestigation.JMedChem.2025Apr24;68(8):8124-8142.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformed