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Inhibitors?ScreeningLibraries?Proteins
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FGFR-IN-18
Cat.No.:HY-172921
分?式:C??H??N?O?
分?量:643.69
作?靶点:FGFR
作?通路:ProteinTyrosineKinase/RTK
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性FGFR-IN-18(CompoundKF7)是?种靶向赖氨酸的FGFR的共价抑制剂，其IC50分别为：1.1nM(FGFR2)、
1.3nM(FGFR1)和31.5nM(FGFR4)。FGFR-IN-18对FGFR3也具有亲和?(10nM时抑制率为52%)。FGFR-
IN-18共价修饰Lys485(FGFR的?个反应位点)。
IC50TargetFGFR2FGFR1FGFR4FGFR3
1.1nM(IC50)1.3nM(IC50)31.5nM(IC50)
REFERENCES
[1].WuX,etal.Residue-SelectiveInhibitorsDiscoveryviaCovalentDNA-EncodedChemicalLibrarieswithDiverseWarheads.JAmChem
Soc.2025May7;147(18):15469-15481.
McePdfHeight
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