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Efzimfotasealfa

Cat.No.:HY-P991210

CASNo.:2746354-58-3

Synonyms:ALXN-1850

作?靶点:Phosphatase

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Efzimfotasealfa(ALXN-1850)是靶向组织?特异性碱性磷酸酶(TNSALP)缺乏的酶替代治疗剂。Efzimfotase

alfa通过?解TNSALP底物，降低?机焦磷酸盐(PPi)和吡哆醛5-磷酸(PLP)等底物的浓度发挥作?。

Efzimfotasealfa有望?于低磷?症(HPP)的研究[1][2]。

REFERENCES

[1].DahirKM,etal.MedicalManagementofHypophosphatasia:ReviewofDataonAsfotaseAlfa.CurrOsteoporosRep.2025Mar

18;23(1):14.

[2].DahirKM,etal.Safety,pharmacokinetics,andpharmacodynamicsofefzimfotasealfa,asecond-generationenzymereplacement

therapy:phase1,dose-escalationstudyinadultswithhypophosphatasia.JBoneMinerRes.2024Sep26;39(10):1412-1423.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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