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文件名称：Dapivirine-d4-TMC120-d-sub-4-sub-生命科学试剂-MCE.pdf
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Dapivirine-d4

Cat.No.:HY-14266S1

CASNo.:1309283-15-5

Synonyms:TMC120-d;R147681-d

44

分?式:C??H??D?N?

分?量:333.42

作?靶点:Isotope-LabeledCompounds;Apoptosis;Reverse

Transcriptase;Autophagy;HIV

作?通路:Others;Apoptosis;Anti-infection;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Dapivirine-d4(TMC120-d4)是氘代标记的Dapivirine。Dapivirine(TMC120)是?芳基嘧啶(DAPY)的原型

，是具有?服活性的?核苷类逆转录酶抑制剂(NRTI)。Dapivirine(TMC120)可直接与HIV的逆转录酶结合。

Dapivirine(TMC120)调节?噬并诱导Akt、Bad和SAPK/JNK的激活。

REFERENCES

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Feb;53(2):211-216.

[2].WeiwenLiu,etal.AntitumorActivityandMechanismofaReverseTranscriptaseInhibitor,Dapivirine,inGlioblastoma.JCancer.2018

Jan1;9(1):117-128.

[3].BrídDevlin,etal.Development