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Inhibitors?ScreeningLibraries?Proteins
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ARantagonist11
Cat.No.:HY-173409
CASNo.:3005979-40-5
分?式:C??H??ClN?O
分?量:336.81
作?靶点:AndrogenReceptor;Ser/ThrProtease
作?通路:VitaminDRelated/NuclearReceptor;Metabolic
Enzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性ARantagonist11(Compoundc2)是?种选择性AR拮抗剂，IC50为0.019μM。ARantagonist11对
ARF877L/T878A突变体也有效(IC50:1.03μM)。ARantagonist11可抑制LNCaP细胞增殖并降低PSA蛋?
表达(IC50：0.54μM)。ARantagonist11可?于前列腺癌(PCa)的研究。
REFERENCES
[1].YuanL,etal.Discoveryofnoveltetrahydroquinolinederivativesaspotent,selective,andorallyAvailableARantagonists.EurJMed
Chem.2025Jul5;291:117566.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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