Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
LIB3S0280
Cat.No.:HY-172620
分?式:C??H??ClN?O?
分?量:460.91
作?靶点:IKK;Akt;Apoptosis
作?通路:NF-κB;PI3K/Akt/mTOR;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性LIB3S0280是?种有效的TBK1抑制剂，IC50值为493.9nM。LIB3S0280可以通过降低IκBα和AKT的磷酸
化来抑制TBK1下游信号传导。LIB3S0280可导致胰腺癌细胞G2/M期停滞并诱导细胞凋亡。LIB3S0280对?
表达TBK1的胰腺癌细胞系表现出显著的抑制作?，96?时的IC50值为6.64-10.98μM。LIB3S0280具有?
于胰腺导管腺癌(PDAC)研究的潜?。
IC50TargetTBK1
493.9nM(IC50)
REFERENCES
[1].Wan-HsiShih,etal.DiscoveryofnovelTANK-BindingKinase1(TBK1)inhibitoragainstpancreaticductaladenocarcinoma.IntJBiol
Macromol.2024Dec;283(Pt1):137296.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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