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Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
EGFR/HER2-IN-17
Cat.No.:HY-172623
分?式:C??H??N?O?
分?量:517.57
作?靶点:EGFR;Caspase;Apoptosis;Bcl-2Family
作?通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性EGFR/HER2-IN-17(Compound7h)是表??长因?受体(EGFR)和?表??长因?受体2(HER2)的双重抑制剂
。EGFR/HER2-IN-17抑制癌细胞增殖。EGFR/HER2-IN-17与EGFR和HER2的结合?袋相互作?，激活
Caspase-3和Caspase-8，降低Bcl-2的表达，从?诱导凋亡(apoptosis)。EGFR/HER2-IN-17有望?于癌症的
研究[1]。
IC50TargetCaspase-3Caspase-8
REFERENCES
[1].Al-WahaibiLH,etal.Design,Synthesis,andComputationalStudiesofNovelPyrazoline-BasedDualEGFR/HER2Inhibitorswith
ApoptoticAntiproliferativeActivity[J].JournalofMolecularStructure,2025:142364.
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