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CB1RAllostericmodulator5

Cat.No.:HY-172587

CASNo.:3019958-44-9

分?式:C??H??Cl?N?O?

分?量:361.22

作?靶点:CannabinoidReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性CB1RAllostericmodulator5(compound3)是?种选择性的、具有?脑屏障通透性的??素受体1型(

Cannabinoidreceptortype1)变构调节剂，其pIC0值为6.89。CB1RAllostericmodulator5在不改变运动活

动的情况下减弱线索诱导的可卡因寻求?为恢复和可卡因诱导的?为敏感化。

REFERENCES

[1].NguyenT,etal.DevelopmentofSquaramidesasAllostericModulatorsoftheCB1Receptor:Synthesis,ComputationalStudies,

BiologicalCharacterization,andEffectsagainstCocaine-InducedBehavioralSensitizationandReinstatementinRats.JMedChem.2025

Apr24;68(8):8694-8712.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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