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RIPK1-IN-29
Cat.No.:HY-170232
分?式:C??H??NO?S
分?量:303.38
作?靶点:RIPkinase
作?通路:Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性RIPK1-IN-29(Compound22)是?种RIPK1抑制剂，IC50为6.9nM。RIPK1-IN-29通过抑制RIPK1发挥抗坏死
性凋亡(Apoptosis)活性。RIPK1-IN-29在TNF-α诱导的炎症体内模型中，10mg/kg剂量可保护??免于体
温过低和死亡。RIPK1-IN-29可?于炎症性疾病领域的研究[1]。
IC50TargetRIPK1
6.9nM(IC50)
REFERENCES
[1].MaL,etal.Discoveryofphenylisoxazolidineanalogstargetingreceptorinteractingproteinkinase1withanti-inflammatoryactivity.EurJ
MedChem.2025Jun5;290:117530.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师