基本信息
文件名称:NLRP3-IN-77-生命科学试剂-MCE.pdf
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文档摘要

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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

NLRP3-IN-77

Cat.No.:HY-171589

CASNo.:2924547-57-7

分?式:C??H??N?O?S

分?量:487.61

作?靶点:NOD-likeReceptor(NLR);InterleukinRelated

作?通路:Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性NLRP3-IN-77(Compound7n)是?种有效的NLRP3inflammasome抑制剂。NLRP3-IN-77抑制THP-1细胞的

活性,IC50值为5.36nM。NLRP3-IN-77能有效降低?细胞介素-1β(IL-1β)和?细胞介素-18(IL-18)的分泌

。NLRP3-IN-77有望?于与NLRP3炎性?体异常激活相关的疾病的研究,如癌症和炎性疾病[1]。

IC50TargetIL-1βNLRP3inflammasome

REFERENCES

[1].AlbaneseV,etal.NovelArylSulfonamideDerivativesasNLRP3InflammasomeInhibitorsforthePotentialTreatmentofCancer.JMed

Chem.2023Apr13;66(7):5223-5241.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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