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Inhibitors?ScreeningLibraries?Proteins
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NLRP3-IN-77
Cat.No.:HY-171589
CASNo.:2924547-57-7
分?式:C??H??N?O?S
分?量:487.61
作?靶点:NOD-likeReceptor(NLR);InterleukinRelated
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NLRP3-IN-77(Compound7n)是?种有效的NLRP3inflammasome抑制剂。NLRP3-IN-77抑制THP-1细胞的
活性,IC50值为5.36nM。NLRP3-IN-77能有效降低?细胞介素-1β(IL-1β)和?细胞介素-18(IL-18)的分泌
。NLRP3-IN-77有望?于与NLRP3炎性?体异常激活相关的疾病的研究,如癌症和炎性疾病[1]。
IC50TargetIL-1βNLRP3inflammasome
REFERENCES
[1].AlbaneseV,etal.NovelArylSulfonamideDerivativesasNLRP3InflammasomeInhibitorsforthePotentialTreatmentofCancer.JMed
Chem.2023Apr13;66(7):5223-5241.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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