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ERβagonist-1
Cat.No.:HY-173474
CASNo.:2412715-30-9
分?式:C??H??O?
分?量:368.55
作?靶点:EstrogenReceptor/ERR;AndrogenReceptor
作?通路:VitaminDRelated/NuclearReceptor
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性ERβagonist-1(Compound8)是?种双重活性的选择性ERβ激动剂(EC50:46.8nM)和AR拮抗剂(IC50:
1555nM)。ERβagonist-1通过结合ERβ激活其信号通路，同时抑制AR的活性。ERβagonist-1在??模型
中保留了ERβ的选择性激动活性，可?于前列腺癌的研究[1]。
IC50TargetERβ
46.8nM(EC50)
REFERENCES
[1].BucknamAR,etal.AnEstrogenReceptorβAgonistwithARAntagonistActivityfromaModernAsymmetricDeNovoSteroidSynthesis.
ACSMedChemLett.2025Mar27;16(4):631-637.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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