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Inhibitors?ScreeningLibraries?Proteins
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AZD-7648(GMP)
Cat.No.:HY-111783G
CASNo.:2230820-11-6
分?式:C??H??N?O?
分?量:380.4
作?靶点:DNA-PK;ATM/ATR;PI3K;Apoptosis
作?通路:CellCycle/DNADamage;PI3K/Akt/mTOR;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性AZD-7648(GMP)是GMP级别的AZD-7648(HY-111783)。GMP级别的?分?可?做细胞疗法中的辅助试剂
。AZD-7648是?种具有选择性的?服有效DNA-PK抑制剂，IC50值为0.6nM,AZD-7648诱导细胞凋亡(
apoptosis)，具有抗肿瘤活性[1]。
IC50TargetPI3KγATMDNA-PKcs
1.37(IC50)17.93(IC50)91.3nM(IC50)
体外研究AZD7648(GMP)(0-30μM)isapotentradiosensitizer[1].
AZD7648(GMP)(3μM)increasessensitivitytoDoxorubicin(HY-15142A)[1].
AZD7648(0.6μM)enhancestheactivityofPARPinhibitorOlaparib(HY-10162)[1].
CellCycleAnalysis[1]
CellLine:IR(ionizingradiation)-treatedA549cellsorA549cells
Concentration:0-30μM
IncubationTime:48h
Result:ArrestedcellcycleatG2/Mphase.
WesternBlotAnalysis[1]