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Inhibitors?ScreeningLibraries?Proteins
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KIM-161
Cat.No.:HY-172964
CASNo.:2559686-28-9
分?式:C??H??N?O?
分?量:439.51
作?靶点:PI3K;Akt;mTOR;Apoptosis;ReactiveOxygenSpecies
作?通路:PI3K/Akt/mTOR;Apoptosis;Immunology/Inflammation;
MetabolicEnzyme/Protease;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性KIM-161是?种PIK3CA抑制剂。KIM-161具有显著的抗增殖活性，对PI3KCA突变乳腺癌MCF7和T47D细
胞的IC50值分别为1.428和1.562μM。KIM-161通过抑制PI3K/AKT/mTOR信号通路，诱导ROS产?诱导细
胞凋亡(apoptosis)和细胞周期阻滞。KIM-161能够?于乳腺癌及其PI3KCA突变亚型的研究[1]。
REFERENCES
[1].AlKharboushDF,etal.ExploringakinaseinhibitortargetingPI3KCAmutantcancercells.JBiomolStructDyn.2025May19:1-18.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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