细胞与分子免疫学课程课件
2Chapter7LymphocyteMaturationandExpressionofAntigenReceptorGenes
3GeneralFeaturesofLymphocyteMaturationThematurationofBandTlymphocytesconsistsof:LineagemitmentandproliferationExpressionofantigenreceptorgenesSelectionofthematurerepertories
4Earlymaturation:PluripotentstemcellsgiverisetoalllineagesofbloodcellsItisdifficulttopreciselydefinethemechanismsbywhichstemcellsbeetothelymphoidlineage、Bcell:boneborrowTcell:thymus3)Bythegenemutationsinexperimentalanimalsorhumanpatients、i、Transcriptionfactorsii、Growthfactorsiii、Growthfactorsreceptor
5Example1Bubbleboydisease1、MutatedinIL-7geneandIL-7receptorgenehaveprofounddeficienciesinmatureTandBcells、2、MutationsinachainoftheIL-2receptorgchain,leadstoanimmunodeficiencydisease:X-linkedseverebinedimmunodeficiencydisease,bubbleboy、
6AntigenReceptorGeneRebinationandExpressionTheremaybe107ormoredifferentTandBlymphocyteclonesinoneindividual,eachcloneproduceonespecificantigenreceptor、Bysomaticrebination,eachindividualdoesnotneedtohavesuchenormouslygenes、Duringthepre-Bcellorpre-Tcellstage,animmatureformofantigenreceptorisformedwhichtotransducesignalstoinducefurthermaturationInmorematurelymphocytes,pleteantigenreceptorexpressed,whichpromotecellmaturation、
7SelectionProcessThatShapetheBandTLymphocyteRepertoiresThepreservationofusefulspecificitiesiscalledpositiveselection:Tcellsinthymus、Bcellsmaturingarenotwellknown、2、Negativeselectionistheprocessthateliminatesdevelopinglymphocyteswithstrongbindingtoself-antigen、
8AcquisitionofFunctionalpetenceBcellscansecreteantibodies、TcellscandifferentiateintodistinctsubsetsofTcells、Expressionofavarietyofcellsurfaceandintracellularmoleculesthatparticipateinlymphocyteactivationandeffectorf