医学微生物学医学免疫学医学寄生虫医学微生物学医学免疫学医学寄生虫医学微生物学医学免疫学医学寄生虫MedicalImmunology医学免疫学
MedicalImmunology医学免疫学
1.Majorconception2.Immunesystem3.Typeofimmuneresponse4.TheHistoryofimmunologyBriefIntroductionChapter1,2免疫学简介
A.Immunity?Classicalconception?Modernconception(immunis)免疫是机体识别自己和非己,并排除非己抗原,以维持机体内环境稳定的生理性防御功能;正常情况下具有保护作用,异常情况下可损害机体（双重性）---机体防御病原体侵袭的能力(或抗感染的防御能力)1.Majorconception
PathogenortoxicproductbodySpecificsubstanceCombinewithAgAbAg→→→body→→→Ab(IS)抗原刺激机体(免疫系统)产生抗体的全过程称为免疫应答(immuneresponse,IR)B.Antigen,antibodyandimmuneresponse
2.Immunesystem(IS)A.ComponentsofimmunesystemB.Functionsofimmunesystem-
?Immuneorgans?centralimmuneorgan?periphericimmuneorganandtissuesA.ComponentsofISimmuneorgansimmunecellsimmunemolecules---bonemarrowandthymus---lymphnodesandspleen?mucosal-associatedlymphoidtissue
bonemarrow*siteofBcelldifferentiationandmutulation*siteofdevelopingresponsemediatedbyBcell*sourseofvariousbloodcells
thymussiteofTcelldifferentiationandmutulationinduceautoimmunetolerancetakepartinimmunoregulationoutercortexinnermedulla---*structureofthymiclobule胸腺小叶的结构TSCincluding:?thymusepithelialcells?macrophage?thymusdendriticcells?fibroblast*containthymocytesandthymicstromalcells(TSC)*functionofthymus
*structure*functionofthymus?shallowcortex(Bcellareas)?paracortex(Tcellareas)cortex?medullarycords髓索(T,B,plasmacellandM?)?medullarysinus髓窦?sitesofresidenceanddevelopingimmuneresponseforTandBcell?filterlymph?takepartinlymphocyterecirculationlymphnodesmedulla75%---T25%---B
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