marks061608YellowMtn药理药效研究肿瘤放疗增敏;UNC
ChapelHill,
NorthCarolina;AlphabetofHope
3D,IGRT,IMRT,TG51,NTCP,EUD,CBCT…;Tumortargeting;GrossTumor
Volume(GTV);GrossTumor
Volume(GTV);GrossTumor
Volume(GTV);RTforGrossDisease
MostlyTumor
Imaginghelps!
e.gProstate,Head/Neck
;;;UNC;Field
Margins;LungRadiosurgery:StageINSCLC;GrossTumor
Volume(GTV);Pieffer,Israel;GrossTumor
Volume(GTV);Imagingonthelinac(reducedmarginforset-uperror);ImageBeforeTx;
*Setup?image?shift?(re-image)?treat
Setup?image?(shift)?treat
3.Setup?image?definetarget?re-plan?treat
4.Setup?image?shift?treat?image?tx..;MetastasesBodyRS;ContinuousOBItodocument
heartsparing;OfflinereviewofOBI,images;CBCT-BasedTargetLocalizationforPartialBreastTreatment;ProspectivestudyofCBCTtodetectsoft-tissueset-uperrorAFTERplannerOBI(Onboardimaging)(Fatunase2006,Duke);GrossTumor
Volume(GTV);NormalTissue;Dose/volume;Dose/volume;Informationoverload.Revenge!;Tablesanddataandlines,toomuch!!;Ergo,themodelers:DVH,NTCP..;UNC;DVH?Outcome;ClearProgress
3DDose/Volumes?Outcome;Parotiddosedrymouth;Dawsonetal.IJROBP53:810-821,2002;Xuetal.IJROBP65:193,2006;FudanUniversity,Shanghai,CancerHospital,GuangxiMedicalUniversity,Nanning,China;;;
;Esophaguscontours:variablearea(volume)
;Superior;esophageal
contours;Acute≥grade2 0.008 0.005
Acute≥grade3 0.05 0.003
Late≥grade1 0.14 0.08 ;MarksIJROBP34:1168,1996;IMRT;NeighborhoodEffects;Bisletal.IJROBP64:1204-1210,2006;PredictorsofBleeding:ProstateCancerTreatedto75.6Gy;3Dvs.IMRT:LungCaPneumonitis;V20--pneumonitis
ReduceV20
Sincedose≈60Gy,use3directions
IncreaseV5
NowV5--pneumonitis;CT;IntegralDose;100;BrainTumor:2to6Beams;Datafromscansofpatientswithbraintumors;ProstateCancer:2to6Beams;Datafromscansofpatientswithprostatetumors;ModifiedfromChapet