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D-erythro-Sphingosine(Standard)

Cat.No.:HY-101047R

CASNo.:123-78-4

分?式:C??H??NO?

分?量:299.49

作?靶点:PKC;Phosphatase;EndogenousMetabolite

作?通路:Epigenetics;TGF-beta/Smad;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性D-erythro-Sphingosine(Standard)是D-erythro-Sphingosine的分析标准品。本产品?于研究及分析应?。

D-erythro-Sphingosine(Erythrosphingosine)是?种?常有效的p32激酶活化剂，EC50为8μM。D-

erythro-Sphingosine抑制蛋?激酶C(PKC)。D-erythro-Sphingosine(Erythrosphing

IC50TargetEC50:8μM(p32-kinase)[1]

PKC[2][3]

REFERENCES

[1].PushkarevaMYu,etal.Regulationofsphingosine-activatedproteinkinases:selectivityofactivationbysphingoidbasesandinhibitionby

non-esterifiedfattyacids.BiochemJ.1993Sep15;294(Pt3):699-703.

[2].KhanWA,etal.ProteinkinaseCandplateletinhibitionbyD-erythro-Sphingosine:comparisonwithN,N-dimethylsphingosineand

commercialpreparation.BiochemBiophysResCommun.1990