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Ursocholicacid(Standard)

Cat.No.:HY-113212R

CASNo.:2955-27-3

分?式:C??H??O?

分?量:408.57

作?靶点:EndogenousMetabolite;EndogenousMetabolite;Apoptosis

作?通路:MetabolicEnzyme/Protease;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ursocholicacid(Standard)是Ursocholicacid的分析标准品。本产品?于研究及分析应?。Ursocholicacid，

?种存在于哺乳动物胆汁中的胆酸，通过??肠道菌群转化为脱氧胆酸(Ursodeoxycholicacid)。Ursocholic

acid作为胆结?溶解剂，在肝脏中通过抗凋亡(apoptosis)作?，抗炎作?，免疫调节作?，胆汁调节作?

，协调线粒体完整性和细胞信号的改变来发挥作?，Ursocholicacid还对慢性胆汁

IC50Target7α-hydroxysteroiddehydrogenase[1],hepatocytenuclearfactor1α[2].

REFERENCES

[1].MacDonaldIA,etal.Formationofursodeoxycholicacidfromchenodeoxycholicacidbya7beta-hydroxysteroiddehydrogenase-

elaboratingEubacteriumaerofaciensstraincoculturedwith7alpha-hydroxysteroiddehydrogenase-elaboratingorganisms.ApplEnviron

Microbiol.1982Nov;44(5):1187-95.

[2].LeeHI,etal.Ursodeoxycholicacid,aninhibitorofhepatocytenucle