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Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

GE1111

Cat.No.:HY-158990

CASNo.:2883669-12-1

分?式:C??H??N?O?

分?量:466.48

作?靶点:Mas-relatedG-protein-coupledReceptor(MRGPR)

作?通路:GPCR/GProtein

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性GE1111是mas相关G蛋?偶联受体X2(MRGPRX2)的拮抗剂，IC50为9.42μM。GE1111抑制肥?细胞脱

颗粒，IC50为4.7μM。GE1111在C48/80(HY-130592)诱发的全?过敏反应模型中表现出抗过敏和抗炎作?

[1]。

IC50TargetIC50:9.42μM(MRGPRX2)

REFERENCES

[1].KumarM,etal.,Mrgprx2antagonistforthetreatmentofpseudoallergicreactions.US20220401435

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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