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FFA2agonist-1
Cat.No.:HY-171069
CASNo.:1312799-06-6
分?式:C??H??ClNO?
分?量:435.9
作?靶点:FreeFattyAcidReceptor
作?通路:GPCR/GProtein
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性FFA2agonist-1(Compound4)是游离脂肪酸受体2(FFA2/GPR43)的激动剂，EC50为81nM。FFA2agonist-
1在β-arrestin-2募集试验和cAMP抑制试验中表现出活性，EC50分别为1.2μM和0.53μM。FFA2
agonist-1可引发?欲调节肽YY(PYY)粘膜反应，抑制脂肪堆积、肠道功能和?物摄?，可?于肥胖研究[1]。
IC50TargetEC50:81nM(FFA2/GPR43)
REFERENCES
[1].HansenAH,etal.,DiscoveryofaPotentThiazolidineFreeFattyAcidReceptor2AgonistwithFavorablePharmacokineticProperties.J
MedChem.2018Nov8;61(21):9534-9550.
McePdfHeight
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