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Inhibitors?ScreeningLibraries?Proteins
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GeX-2
Cat.No.:HY-P10898
CASNo.:2900996-95-2
分?式:C???H???N??O??
分?量:2441.72
Sequence:GRYRSPYDRRRRYRRITD-NH2
SequenceShortening:Gly-Arg-Tyr-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Arg-
Arg-Ile-Thr-Asp-NH2
作?靶点:nAChR;CalciumChannel;GABAReceptor
作?通路:MembraneTransporter/IonChannel;NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性GeX-2是αO-conotoxin的截短类似物。GeX-2可激活GABAB受体。GeX-2可抑制α9α10nAChR和CaV2.2
通道。GeX-2可缓解??慢性压迫性损伤模型中的疼痛[1]。
REFERENCES
[1].LiX,etal.DualAntagonismofα9α10nAChRandGABABReceptor-CoupledCaV2.2ChannelsbyanAnalgesicαO-Conotoxin
Analogue.JMedChem.2024Jan25;67(2):971-987.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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