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Probucoldithiobisphenol

Cat.No.:HY-W424839

CASNo.:6386-58-9

Synonyms:DTBP

分?式:C??H??O?S?

分?量:474.76

作?靶点:Hemeoxygenase(HO)

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Probucoldithiobisphenol(DTBP)是Probucol(HY-B0388)的衍?物。Probucoldithiobisphenol诱导?红素

加氧酶1(HO-1)的产?，并表现出抗氧化活性。Probucoldithiobisphenol在ApoE?/???模型中抑制主动脉

的动脉粥样硬化病变，在兔动脉损伤模型中促进动脉再内?化并抑制再狭窄。Probucoldithiobisphenol具有

?服活性[1]。

REFERENCES

[1].WuBJ,etal.,Antioxidantsprotectfromatherosclerosisbyahemeoxygenase-1pathwaythatisindependentoffreeradicalscavenging.

JExpMed.2006Apr17;203(4):1117-27.

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