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(E)-XS-060
Cat.No.:HY-149085A
CASNo.:2787626-06-4
分?式:C??H??N?O?
分?量:334.37
作?靶点:RAR/RXR
作?通路:MetabolicEnzyme/Protease;VitaminDRelated/Nuclear
Receptor
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性(E)-XS-060是XS-060的异构体。XS-060是RXRα拮抗剂。XS-060抑制pRXRα-PLK1相互作?。XS-060诱
导RXRα依赖性有丝分裂停滞。XS-060对乳腺癌、肺腺癌和肝癌表现出良好的抗肿瘤活性。
IC50TargetRXRα
REFERENCES
[1].ChenJ,etal.DiscoveryofbipyridineamidederivativestargetingpRXRα-PLK1interactionforanticancertherapy.EurJMedChem.
2023Jun5;254:115341.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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