Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
dCNP
Cat.No.:HY-P10869
分?式:C???H???N??O??S?
分?量:3147.91
Sequence:{LysC18acid}-Lys-Lys-Lys-Gly-Gly-Gly-Gly-Leu-Ser-Lys-Gl
y-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-
Gly-Leu-Gly-Cys(disulfidebridge:Cys13-Cys30)
SequenceShortening:{Lys}-KKKGGGGLSKGCFGLKLDAIGSMSGGLGC(disulfide
bridge:Cys13-Cys30)
作?靶点:NatriureticPeptideReceptor(NPR)
作?通路:GPCR/GProtein
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性dCNP与NPR-B/C受体(NPR-B/Creceptor)结合，激活cGMP信号通路，调节?管功能。dCNP通过下调HIF1
α、HIF2α等缺氧相关基因表达，发挥抗缺氧作?。dCNP抑制肿瘤基质的诱导，具有抗纤维化作?。dCNP
上调肿瘤中的CTL、NK细胞、常规1型树突状细胞，激活免疫反应[1]。
REFERENCES
[1].LuZ,etal.,ModifiedC-typenatriureticpeptidenormalizestumorvasculature,reinvigoratesantitumorimmunity,andimprovessolid
tumortherapies.SciTranslMed.2024Aug21;16(761):eadn0904.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.